SIRTUINS AND VASCULAR AGING
نویسندگان
چکیده
منابع مشابه
FOXOs and sirtuins in vascular growth, maintenance, and aging.
Blood vessels form the first organ in the developing embryo and build extensive networks that supply all cells with nutrients and oxygen throughout life. As blood vessels get older, they often become abnormal in structure and function, thereby contributing to numerous age-associated diseases including ischemic heart and brain disease, neurodegeneration, or cancer. First described as regulators ...
متن کاملSirtuins, aging, and metabolism.
Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on two key mammalian sirtuins, SIRT1 (which r...
متن کاملSirtuins, aging and diseases
SIR2 and related genes (sirtuins) are NAD-dependent deacetylases that link metabolism, protein acetylation and aging in a variety of species. Sirtuins are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian sirtuins SIRT1-7 are involved in changes in stress resistance and metabolism that are triggered by CR, which not only extends life span, but also p...
متن کاملRetinal aging and sirtuins.
The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging. Cells containing unstable DNA are biologically vulnerable, and if the DNA damage is too great for the cell to repair, it becomes senescen...
متن کاملSirtuins, Aging, and Medicine
Copyright © 2011 Massachusetts Medical Society. Populations in developed countries continue to grow older, as medical advances allow baby boomers to march inexorably onward. Many of the most important diseases that lead to disability and death occur late in life, indicating that aging itself is a key risk factor. Recent research into the science of aging has identified genes and pathways that a...
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ژورنال
عنوان ژورنال: International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований)
سال: 2020
ISSN: 1996-3955
DOI: 10.17513/mjpfi.13159